About Us

We are located in the Lewis-Sigler Institute for Integrative Genomics at Princeton University, a hub of interdisciplinary science.

We seek to build and maintain an environment that integrates the most exciting advances in cell biology, genomics, computational biology, and computer science.

We are always looking out for new members with expertise in one of these areas and who are fearless about learning others.

Contact Britt if you are interested in joining us or see our Join Us page.

Research Overview

How do cells coordinate complex responses to DNA damage?

To respond to stimuli, cells must coordinate the activity of many of factors. Our lab is interested in understanding how such coordination is achieved, especially when cells are faced with deleterious conditions (e.g., stress and damage). We have particular interest in understanding mechanisms of DNA damage response.

How can we improve technologies for genome editing and functional genomics?

To enable our work, we use and develop cutting-edge experimental tools, including genome editing technologies and genetic screening methods. Our tools, which leverage recent advances in CRISPR-based genetics, single-cell RNA-sequencing, and genetic interaction mapping, allow us to systematically interrogate gene function, often at genome-scale, in high resolution, and/or with less bias than conventional methods. We have particular interest in understand how endogenous cellular mechanisms enable or suppress genome editing tools.

Application of technology development efforts to diverse areas of biology

We also apply our tools to support collaborative studies in diverse areas of biology, including virology, immunology, and development.

Recent News

April 2024: Jun’s manuscript is published at Nature!

Wode passes his general exam with distinction- Congrats Wode!

March 2024: Ann and Danny’s paper goes live on bioRxiv!

February 2024- More screens await: Aaron cuts the “ribbon” on our new cell culture room!

Our collaboration with the Posfai lab demonstrating efficient prime editing in two-cell mouse embryos is finally out in Nature Biotech! Congrats to co-author Ryan, as well as all authors.

Our first graduate student defends their thesis in their Princeton Final Public Oral (FPO)! Congrats to Dr. Danny Simpson-the lab is so excited to see all the amazing science you will continue to do in the future

December 2023- Weihao passes his general exam- Congrats Weihao!

October 2023- Danny presents at the MOL Retreat in Long Branch, NJ!

August 2023- Britt co-organizes and presents at the CSHL Genome Engineering: CRISPR Frontiers Meeting!

Danny presents a poster and Jia gives a talk at CSHL. Congrats to them both!

Danny and Jia’s work on mapping the genetic interaction network of PARP inhibitor response goes live on bioRxiv!

M3Seq is accepted and published at Nature Microbiology.

June 2023- Sabrina and Britt’s collaboration with LSI Scholar Harry McNamara is live on BioRxiv!