About Us

We are located in the Lewis-Sigler Institute for Integrative Genomics at Princeton University, a hub of interdisciplinary science.

We seek to build and maintain an environment that integrates the most exciting advances in cell biology, genomics, computational biology, and computer science.

We are always looking out for new members with expertise in one of these areas and who are fearless about learning others.

Contact Britt if you are interested in joining us or see our Join Us page.

Research Overview

How do cells coordinate complex responses to DNA damage?

To respond to stimuli, cells must coordinate the activity of many of factors. Our lab is interested in understanding how such coordination is achieved, especially when cells are faced with deleterious conditions (e.g., stress and damage). We have particular interest in understanding mechanisms of DNA damage response.

How can we improve technologies for genome editing and functional genomics?

To enable our work, we use and develop cutting-edge experimental tools, including genome editing technologies and genetic screening methods. Our tools, which leverage recent advances in CRISPR-based genetics, single-cell RNA-sequencing, and genetic interaction mapping, allow us to systematically interrogate gene function, often at genome-scale, in high resolution, and/or with less bias than conventional methods. We have particular interest in understand how endogenous cellular mechanisms enable or suppress genome editing tools.

Application of technology development efforts to diverse areas of biology

We also apply our tools to support collaborative studies in diverse areas of biology, including virology, immunology, and development.

Recent News

June 2025- Britt receives a Princeton IP Accelerator Award!

May 2025- Ann defends her FPO! Congrats Dr. Cirincione!

Britt hoods lab alumni Jun and Ann at Princeton Commencement.

Senior Milan graduates and is heading off to start her PhD at Duke this fall. Congratulations!

Wode gives an excellent talk at the annual Midwest DNA Repair Symposium!

The lab hangs out to celebrate a year of accomplishments- including Britt getting promoted to Associate Professor!

April 2024- Xukai Gao (MOL) joins the lab. Welcome!

November 2024- The lab’s work on a benchmarked, high-efficiency prime editing platform for multiplexed dropout screening is now live at Nature Methods! Congrats to all authors, especially co-firsts Ann and Danny! This work is also featured in Nature Methods News and Views.

October 2024- More fun at Princeton retreats- Ann gave a great talk at the LSI retreat this month!

Our collaborative work with LSI Scholar Harry McNamara and Jared Toettcher is out at Nature Cell Bio! Congrats to all authors!

Britt is featured in STAT Who to Know: 10 Scientists leading a new generation of gene editors developing CRISPR medicines!

September 2024- Lab alumni Danny and Purmina join the Adamson lab for a celebratory lab dinner!

The lab had a great time at the MOL retreat: Wode gave an excellent talk, and both Ann and Jia shared their work at posters. We are also proud of Aaron for being awarded the Distinguished Postdoc Service Award, and Sabrina for being awarded the Thomas J. Silhavy Graduate Advocacy Prize. Congrats to all!